Blar i forfatter "von Hofsten, Susannah"

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    • Amphipathic barbiturates as marine product mimics with cytolytic and immunogenic effects on head and neck squamous cell carcinoma cell lines 

      von Hofsten, Susannah; Langer, Manuel K; Korelin, Katja; Norvoll Magnussen, Synnøve; Ausbacher, Dominik; Anderssen, Trude; Salo, Tuula; Strøm, Morten B.; Bayer, Annette; Al-Samadi, Ahmed; Berge, gerd (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-30)
      The incidence of head and neck squamous cell carcinoma (HNSCC) is increasing and the conventional treatments for this form of cancer can be tough. Despite the success of existing immunotherapies in some HNSCC patients, many do not respond to this type of treatment. Thus, the development of novel anti-cancer therapies should be prioritized. In the current study, the anticancer activity of a panel ...

    • Anticancer activity of amphipathic barbiturates 

      von Hofsten, Susannah (Doctoral thesis; Doktorgradsavhandling, 2023-06-20)
      Cancer is one of the leading causes of death worldwide. Challenges related to drug resistance, side effects, and poor response rates makes cancer treatment complicated. However, different forms of immunotherapy have been effective for some cancer patients. Oncolytic therapies which can be administered directly intratumorally represent a promising form of immunotherapy. The aim of oncolytic therapies ...

    • Exploring the in vitro expansion of CD4 T cells. For improved culturing of CD4 T cells linked to FNAIT 

      von Hofsten, Susannah (Master thesis; Mastergradsoppgave, 2018-05-15)
      Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare disease that may cause serious bleedings in the fetus or neonate of a woman who has developed antibodies against the fetus’ platelets. Development of FNAIT has been linked to the presence of platelet reactive CD4 T cells that help B cells to develop into antibody producing plasma cells. To be able to conduct research on such T cells, ...

    • The Marine Natural Product Mimic MHP88 Shows Anticancer Activity and has the Potential to Cause Immunogenic Cell Death 

      von Hofsten, Susannah; Norvoll Magnussen, Synnøve; Ausbacher, Dominik; Paulsen, Marianne Hagensen; Bayer, Annette; Strøm, Morten B.; Berge, Gerd (Conference object; Konferansebidrag, 2020-03)
      The marine natural product mimic MHP 88 is a novel synthetic molecule based on unique structures found in molecules from an arctic marine bryozoan. Initial studies showed that MHP88 kills cancer cells efficiently, but is not hemolytic. In this study, we look closer at the mode of death induced by MHP88 in oral cancer (HSC-3) and lymphoma (Ramos) cell lines. Immunogenic cell death (ICD) is a mode of ...

    • The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines 

      von Hofsten, Susannah; Paulsen, Marianne Hagensen; Magnussen, Synnøve; Ausbacher, Dominik; Kranz, Mathias; Bayer, Annette; Strøm, Morten Bøhmer; Berge, Gerd (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-16)
      Bioprospecting contributes to the discovery of new molecules with anticancer properties. Compounds with cytolytic activity and the ability to induce immunogenic cell death can be administered as intratumoral injections with the aim to activate anti-tumor immune responses by causing the release of tumor antigens as well as damage-associated molecular patterns (DAMPs) from dying cancer cells. In ...

    • The pH-Responsive Liposomes—The Effect of PEGylation on Release Kinetics and Cellular Uptake in Glioblastoma Cells 

      Rustad, Eirik André Lindeløff; von Hofsten, Susannah; Kumar, Robin; Lænsman, Eirik Abrahamsen; Berge, Gerd; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-25)
      Nanomedicine has been, to a certain degree, a success story in the development of superior anticancer therapies. However, there are tumors that remain a huge challenge for nanoformulations, for instance, brain tumors such as glioblastoma, the most common and aggressive brain tumor. To utilize the fact that such tumors are characterized by an acidic extracellular environment, we selected pH-responsive ...

    • The selectivity of galardin and an azasugar-based hydroxamate compound for human Matrix metalloproteases and bacterial metalloproteases 

      Sylte, Ingebrigt; Dawadi, Rangita; Malla, Nabin; von Hofsten, Susannah; Nguyen, Tra-Mi; Solli, Ann Iren; Berg, Eli; Adekoya, Olayiwola A.; Svineng, Gunbjørg; Winberg, Jan-Olof (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-03)
      Inhibitors targeting bacterial enzymes should not interfere with enzymes of the host, and knowledge about structural determinants for selectivity is important for designing inhibitors with a therapeutic potential. We have determined the binding strengths of two hydroxamate compounds, galardin and compound 1b for the bacterial zinc metalloproteases, thermolysin, pseudolysin and auerolysin, known to ...